Neuromodulators, Botox and Dysport, are used in treating facial wrinkles such as in the forehead, between the eyes, and in the “crows feet” areas. Botulinum toxin works by weakening the muscles of facial expressions. Once the resting tone of the treated muscles are weakened, the pull of the muscles relax and the overlying skin flattens. By physiologically weakening the muscles, wrinkles are lessened naturally. This approach is different from dermal fillers which work by filling in wrinkles or depressions.